4EVR™

• Healthy aging*
• Healthy cognitive function*
• Healthy glucose metabolism*
• Cardiovascular health through healthy cholesterol metabolism*
• Healthy liver function*
• Gastrointestinal health*
• Healthy immune function*
• Cellular protection from oxidative stress*
• The body’s natural detoxification processes*
• Phase I, II and III detoxification*
• The metabolism and elimination of certain environmental pollutants*
• Healthy glutathione levels*
• Estrogen metabolism and detoxification*

• Featuring Sulforaphane Activation Technology™
• Designed to optimize sulforaphane production, protect stability, and support reliable delivery
• Optimized for endogenous and exogenous sulforaphane production
• Patent-pending technology platform
• Proprietary manufacturing know-how and trade secrets
• Analytical validation to support measurable formulation development
• Science-led applications for healthy aging and condition-specific formulations
• Builds on sulforaphane research exploring biological pathways associated with all 12 Hallmarks of Aging
• Ongoing 4EVR™ clinical studies
• May be blended with other ingredients for the intended application

• 4EVR^TM Proprietary Sulforaphane Activation Technology 600 mg**

Sulforaphane research explores the following mechanisms:

• Activation of NRF2-mediated cellular defense pathways through modification of KEAP1 sensor proteins*
• Modulation of NF-κB and TLR4 signaling involved in the cellular response to inflammatory stimuli*
• Regulation of gene expression through histone acetylation and other epigenetic mechanisms*
• Activation of heat shock responses involved in cellular protein maintenance*
• Enhancement of proteasome activity involved in protein turnover*
• Modulation of autophagy and lysosomal pathways involved in cellular recycling*
• Modulation of mitochondrial biogenesis, dynamics, and stress responses*
• Modulation of nutrient-sensing and cellular energy pathways*

For trade use only. Supporting studies differ in ingredient form, dose, population, and design. Mechanistic findings may come from cell or animal studies and do not establish clinical benefits of the finished 4EVR™ product. See the 4EVR™ sell sheet for supporting references.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

• For foundational formulations, use an amount of 4EVR™ analytically validated to yield 15 mg of sulforaphane daily.
• Application-specific formulations and suggested-use guidance are developed through the 4POTENTIA® formulation platform, with serving sizes informed by relevant scientific evidence.

• Allergens
• GMOs
• Gluten
• BSE/TSE